Akkermansia-BPC-Complex

ABC (Akkermansia-BPC-Complex) provides a new approach to cellular longevity via gut health and metabolic optimization. Informed by the latest research on microbiome profiles in Centenarians. this "first-of-it's-kind" formulation is at the cutting edge of longevity science. Two primary areas emerge from the data as being critical for longevity: gut barrier integrity and metabolic function, especially as it relates to GLP-1. ABC is designed specifically to harness the synergistic power of Akkermansia, BPC-157, and Sunfiber® to support metabolic optimization and microbiome profiles found amongst blue zone Centenarians.

AKKERMANSIA & BPC-157 BASICS 

First. it is important to understand the biochemical role Akkermansia muciniphila plays in the gut as it relates to metabolic health. It all comes down to its interactions with glucagon-like peptide-1 (GLP-1), an important hormone produced by the intestinal cells, which plays a vital role in regulating glucose metabolism and insulin secretion. Akkermansia muciniphila 

is known to increase the production and secretion of GLP-1 in the intestine by utilizing mucin, a glycoprotein present in the mucus lining of the gut. as its primary source of energy.1 During the process of mucin degradation, Akkermansia releases metabolites that stimulate the intestinal L-cells to secrete more GLP-1.2 The increased levels of GLP-1 then act on various tissues, such as the pancreas, liver, and muscles, to promote better glucose control, support insulin sensitivity, and regulate appetite. ultimately contributing to improved metabolic health.3 

BPC-157, on the other hand, plays an important supporting role via its effects on gut tissue and barrier integrity. This peptide is responsible for maintaining and continuously supporting the intestinal architecture. which allows the myriad of chemical interactions to occur without interrupt ion within the gut ecosystem. 

BPC-157 / AKKERMANSIA SYNERGY 

Because the biochemical relationship between Akkermansia and the intestinal barrier is heavily dependent on a high level of structural integrity within the gut lining, BPC-157 serves as the ideal companion. As BPC-157 plays a vital role in rejuvenating and maintaining gut tissues, supporting barrier function, it creates the optimaI environment for Akkermansia's broad biochemical function. 

Additionally, Sunfiber serves as a rich prebiotic source for short-chain fatty acid production, in particular butyrate. As a trio. they all work in harmony to support a healthy gut microbiome, improve nutrient absorption and optimize metabolic function. This synergistic interaction lays the foundation for longevity by fostering a resilient gut environment that contributes to overall healthspan and vitality. 

1.     Derrien, M. et al. (2004). Mucin-degrading bacteria from human colonic mucosa. Bulletin of the IDF, 388, pp.107-112. 

2.     Plovier. H. et al. (2017). A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice. Nature Medicine, 23(1), pp.107-113. 

3.     Baothman OA, Zamzami MA, Ta her I, Abu baker J, Abu-Farha M. The role of Gut Microbiota in the development of obesity and Diabetes. Lipids Health Dis. 2016 Jun 18;15:108. 

4.     Rodrigues VF, Elias-Oliveira J, Pereira fs. Pereira JA, Barbosa SC, Machado MSG, Carlos D. Akkermansia muciniphila and Gut Immune System: A Good Friendship That Attenuates Inflammatory Bowel Disease. Obesity, and Diabetes. Front lmmunol. 2022 Jul 7;13:934695. 

5.     Depommier C., Everard A., Druart C .. Plovier H .. Van Hui M .. Vieira-Silva S., Falony G .. Raes J., Maiter D., Delzenne N.M .. et al. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: A proof-of-concept exploratory study. Nat. Med. 2019;25:1096-1103. 

6.     Wang z. Cui S, Zhang T, Wang W, Li J, Chen YQ. Zhu SI. Akkermansia muciniphila supplementation improves glucose tolerance in intestinal Ffar4 knockout mice during the daily light to dark transition. mSystems. 2023 Oct 26;8(5):e0057323. 

7.     Everard A., Belzer C .. Geurts L. Ouwerkerk J.P .. Druart C .. Bindels LB., Guiot Y .. Derrien M .. Muccioli G.G .. Delzenne N.M .. et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc. Natl. Acad. Sci. USA. 2013;110:9066-9071. 

8.     Deng L. Ou z .. Huang D .. Li C., Luz .. Liu w .. Wu F .. Nong C .. Gao J .. Peng Y. Diverse effects of different Akkermansia muciniphila genotypes on Brown adipose tissue inflammation and whitening in a high-fat-diet murine model. Microb. Pathog. 2020;147:104353. 

9.     Ai X. Liu Y. Shi J, Xie X, Li L, Duan R. Lv Y, Xiong K. Miao Y, Zhang Y. Structural characteristics of gut microbiota in longevity from Changshou town. Hubei, China. Appl Microbial Biotechnol. 2024 Apr 15;108(1):300.